When it comes to chronic lung disease, early detection and ongoing monitoring are key. But traditional methods like bronchoscopy are invasive, expensive and often impractical for follow-ups. That’s why Professor Åsa Wheelock and her team at Karolinska Institutet are turning to PExA, a non-invasive method that collects microscopic particles from the deep lungs—through a simple breathing maneuver.
The team is developing protocols to detec microRNAs (miRNAs)—tiny molecules that regulate gene expression and hold strong potential as biomarkers. Despite the challenge of working with extremely low material volumes, they recently became the first to detect miRNA using PExA.
Non-invasive, repeatable sampling
Access to deep lung biomarkers
Cost-effective compared to bronchoscopy
Enables longitudinal patient studies
Easy to use in outpatient or even primary care settings
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